Cancer’s “Master Switch” Blocked for Good in Landmark Study
29th March 2025
For the first time, scientists have identified promising drug candidates that irreversibly bind to a notoriously “undruggable” cancer protein, effectively and permanently disabling it.
Transcription factors, proteins that act as master regulators of gene expression, play a critical role in cancer development. Despite years of effort, designing small-molecule drugs to block these proteins has proven largely ineffective. As a result, researchers have recently turned their attention to peptides, short chains of amino acids, as a potential solution for targeting these elusive proteins.
Now, a team from the University of Bath has developed a breakthrough method to discover peptides that can selectively and irreversibly bind to transcription factors inside cells. Using this approach, they have successfully blocked a key cancer-driving transcription factor known as cJun, marking a significant step forward in targeting previously untreatable cancer mechanisms.